Connected and automated driving confronts critical complex traffic scenarios and safety, which attracts increasing attention from academia and industry. To enhance the intelligent safety for connected and automated vehicles (CAVs), including functional safety, safety of the intended functionality (SOTIF), and cybersecurity, efforts are required to seek solutions from fundamental theory, guarantee framework and general/systematic point of view. This feature topic aims to provide a platform for academia, industry, and policymakers, on which they could present the latest research and engineering experience in developing and applying novel technologies. The topics cover SOTIF, cybersecurity, artificial intelligence for CAV safety, risk assessment-based vehicle path planning and decision-making under uncertain environments.